1 having the power to propel; "propulsive coefficient"
2 tending to or capable of propelling; "propellant fuel for submarines"; "the faster a jet plane goes the greater its propulsive efficiency"; "universities...the seats of propulsive thought" [syn: propellant, propellent, propelling]
Prokinetics are a class of drugs used on the digestive system. It includes all drugs whose primary effect is to augment the speed of intestinal transit, by increasing the frequency of contractions in the small intestine or making them stronger, but without disrupting their rhythm. They are mostly used to treat or prevent pathological gastroesophageal reflux, or to speed up absorption of certain other drugs. Some of them can also be used to help in the treatment of nausea or other symptoms associated with dyspepsia. Most of these drugs are grouped under ATC code A03F.
Cisapride acts on 5HT4 receptor. Its metabolised by CYP3A4 so when combined with enzyme inhibitors as ketoconazole, erythromycin the increased serum level can produce prolonged QT interval in ECG and serious cardiac arrythmia.
Parasympathomimetics as bethanechol. They increase motility and secretions as well as motilin like agents e.g. erythromycin.
Examples of this class of drug are:
- Hardman JG, Limbird LE, Gilman AG. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York: McGraw-Hill, 2001. ISBN 0-07-135469-7.
propulsive in German: Prokinetikum
propulsive in Spanish: Procinético